I’m having a similar problem with my RME interface and win 10. I launch EZMix 2 standalone set the interface buffer to 44100 and it works ok for a while, but slowly begins to degrade in audio quality with crackles and stuttering to the point of it being useless.
New recent build:
z490 intel MB (Note this board has built in audio so it could be something conflicting – tried disabling – no luck)
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